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Serotonin Syndrome Symptoms

Easily annoyed, Craze, Change, Fits, Restlessness, Increased middle rate, Sweating, Shivering, Tremor, Cerebral status changes, Restlessness, Increased reflexes, Increased reflexes, Stiffness, Moving, Pain in the stomach, Diarrhea, Perspiration, Increased heat, High blood pressure. Just about all these tend to be signs of serotonin syndrome. All will come typically within the first 24 hours right after taking a particular overdose of serotonin drugs. This symptoms are on cognitive level, autonomic level and SoNS level. Serotonin Syndrome appear often after o.d. of serotonin drugs and also drug combination that increase synaptic serotonin. Drugs that are know to stimulate high levels of serotonin are: MAOIs, TCAs, SSRIs, SNRIs, Bupropion, Tramadol, Fentany, Oxycodone, Hydrocodone, MDMA, MDA, Amphetamine, Sibutramine, Crack, Triptans, LSD, Panax Ginseg, Nutmed, Yohimbe, Syrian Rue, Ritonavir, Granisetron, Olanzapine, Valproate, Buspirone, Li, Linezolid, Dextromethorphan, Risperidone, Trypthophan, L-Dopa, Valproate, Amphetamine. Due to the fact serotonin toxicity it's definitely not tested in the laboratory for diagnosis, signs or symptoms tend to be the one that need observed. The number one set of criteria to use to diagnose serotonin toxicity is Hunter Serotonin Toxicity Criteria.

Treatment for serotonin syndrome are as follows: discontinuing drugs that created the o.d. posible and also drugs that can contribute management of serotonin antagonist (eg. cyproheptadine) for sever cases of toxicity for agitation, muscle stiffness and seizure like movements, benzodiazepines (Valium, Ativan) Intra venous liquids Because serotonin syndrome is definitely not simple to diagnose, prevention is wanted for any 5-hydroxytryptamine drugs mixture of which may lead to 5-hydroxytryptamine toxicity.

Dunkley, EJ, Isbister, GK, Sibbritt, D, Dawson, AH, Whyte, IM, The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity, QJM 2003; 96:635-642 Prator BC. Serotonin Syndrome. J Neurosci Nurs. 2006 Apr;38(2):102-5. Ford MD, Clinical Toxicology. 1st ed. Philadelphia, Pa: WB Saunders; 2001:150, 522, 547, 550.